Inflammation Can Harm Your Liver
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Liver conditions are an epidemic. Fatty liver, hepatitis and cirrhosis of the liver are a significant health problem for people in most parts of the world. These conditions can range from being fairly mild to being life threatening. Did you know that the level of inflammation you have in your body influences the severity of a liver disease? This is especially the case for cirrhosis of the liver.
Cirrhosis occurs as a result of long term damage to the liver. Eventually scar tissue replaces normal healthy liver cells, leaving the liver unable to carry out its functions. The liver becomes unable to cleanse and filter the bloodstream adequately; hence waste products accumulate and adversely affect other parts of the body. When waste products reach the brain, they disrupt normal mental function and nerve function; this is referred to as hepatic encephalopathy. Patients with cirrhosis of the liver also commonly experience a disruption to the heart’s normal rhythm.
Researchers from the University College London Medical School decided to measure the level of cytokines in the bloodstream of cirrhosis patients. Cytokines are inflammatory molecules. They are released by immune cells, fat cells and some other cells of the body in response to tissue damage. The study recruited 80 patients with cirrhosis of the liver and 11 healthy people with no liver disease. The participants were assessed for the presence of hepatic encephalopathy through various cognitive tests and a brain scan (electroencephalogram). They were also checked for any heart abnormalities with an electrocardiogram. Lastly the researchers measured the levels of cytokines in the participants’ bloodstream; one of them being the inflammatory chemical interleukin-6.
In their studies, the scientists discovered that higher blood levels of cytokines (particularly interleukin-6) are strongly associated with a worsening of both mental and cardiac function in people with cirrhosis of the liver. All cirrhosis patients have elevated levels of inflammatory chemicals compared to healthy people. As cytokine levels rise, the complications of cirrhosis increase.
Inflammation is the body’s response to infection, injury or allergies. Acute inflammation occurs as a result of conditions such as a sprained ankle or a blister; however inflammation can also occur in a subtle, chronic form. Several factors promote inflammation in the body, these include:
The above statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.
Reference: https://journals.physiology.org/doi/full/10.1152/ajpgi.00152.2012
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