Is Leptin Resistance The Reason You Can’t Lose Weight?
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- Is Leptin Resistance The Reason You Can’t Lose Weight?
Have you heard of the hormone leptin? It has very important functions in your body that regulate appetite and metabolism. In the majority of overweight people, leptin no longer functions properly. Restoring leptin sensitivity can make it easier to achieve your desired body weight.
Leptin is a hormone made by your fat cells that tells your brain when you have enough body fat. This is supposed to prevent overeating and help you maintain a healthy body weight. Leptin resistance is a condition where the brain no longer responds to this signal, which may contribute to obesity. Weight gain and loss is about much more than calories, exercise and willpower. Leptin is a hormone with a powerful effect on appetite and weight loss. In fact, leptin resistance is now believed to be the leading driver of fat gain in humans.
Leptin is often referred to as the satiety hormone. Its primary target is an area of the brain called the hypothalamus. Leptin is supposed to tell your brain that you have enough fat stores on your body and you don’t need to eat any more food.

In some overweight people, leptin has been so high for so long that the brain no longer responds to it. This is a problem because a person with leptin resistance can feel dissatisfied after a meal. They continue to feel hungry and would like to eat more. This can make sticking to a diet impossibly difficult.
Leptin is produced by your fat cells. The more body fat you carry, the more leptin you’ll produce, which you can eventually become resistant to. If copious amounts of leptin are present, the brain no longer notices it. When your brain doesn’t receive the leptin signal, it mistakenly thinks that your body is starving even though it has more than enough energy stored. This can increase hunger and cause a person to burn fewer calories when they exercise.


If you are suffering with a health problem that raises inflammation in your body, try to address that. Inflammation can stand in the way of weight loss because it makes it harder for leptin and insulin to function properly. There is a great deal of helpful information in our book Healing Autoimmune Disease: A plan to help your immune system and reduce inflammation.
The above statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.
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