Perimenopause May Trigger Anxiety Or Depression
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- Perimenopause May Trigger Anxiety Or Depression
Did you know it’s common to experience anxiety or depression for the first time during the years leading up to menopause? The sharp hormonal swings in the lead up to menopause can impair a woman’s stress coping abilities. Poor mental health, mood difficulties, sleep problems and unpleasant physical symptoms are all typical during the perimenopause years.
Perimenopause is the two to twelve years before menopause. It typically begins when a woman is in her mid 30s. It can cause heavy periods, irregular periods, mood swings, insomnia, and night sweats.
The World Health Organization defines perimenopause as ‘the time immediately preceding the menopause, beginning with endocrine, biologic and clinical changes, and ending a year after the final menstrual period’. Menopause is the phase that begins one year after the last period, or when the blood level of Follicle Stimulating Hormone (FSH) is 30 or above. The first few years of menopause typically cause hot flushes, weight gain around the torso, and insomnia. Perimenopausal and menopausal symptoms can usually be relieved with natural treatments.
Your progesterone level will drop long before estrogen does. That means in your forties you may find you don’t cope with stress as well as you used to. This happens because losing progesterone during perimenopause can destabilise your HPA axis (hypothalamic-pituitary-adrenal) axis. This describes the way your brain and adrenal glands communicate with each other when you are stressed. Impaired function of this system is why perimenopause is associated with an increased risk of anxiety, depression and insomnia.
During perimenopause you still produce estrogen, but the rise and fall is no longer as smooth. Dramatic swings in oestrogen are more common and this also adversely affects mood.

Your progesterone can be converted to the calming anti inflammatory steroid allopregnanolone (ALLO), progesterone calms GABA receptors and it stabilises the hypothalamic pituitary adrenal axis. Progesterone also promotes neurogenesis (new nerve growth) in the hippocampus, further supporting healthy brain function.
A recent study called Estradiol and Progesterone as Resilience Markers showed that lower progesterone during perimenopause is associated with lower life satisfaction, greater levels of perceived stress, and increased risk of depression and anxiety.
Perimenopause can cause extremely distressing symptoms for a lot of women. It is typically a challenging phase of life anyway, and the hormonal swings only worsen symptoms. Fortunately there are natural remedies to help.
The above statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.
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