Berberine Helps Prevent and Treat Yeast Infections
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- Berberine Helps Prevent and Treat Yeast Infections
Vaginal candidiasis is a vaginal yeast infection, mostly caused by a fungus called Candida albicans. It’s extremely common; around three out of four women get it at some point during their reproductive years.
Doctors have used antifungal medications to treat it for a long time, but the fungus is increasingly becoming resistant to these drugs, so they don’t always work well anymore. The other problem is the infection comes back once the medication is stopped. Anti fungal drugs can be toxic to the liver.
For the yeast to cause an infection, it first has to stick (adhere) to the cells lining the vagina. Earlier research found that this sticking step is a key part of how the infection takes hold. If you can stop the yeast from sticking in the first place, you might be able to prevent or treat the infection more effectively, even in cases where it’s become drug-resistant.

Berberine is a natural compound found in certain plants, and it’s been used traditionally to treat this kind of infection. Until recently, scientists didn’t really understand how it worked at a cellular level. The researchers showed that berberine reduces the yeast’s ability to stick to vaginal cells in two main ways:
–It lowers the levels of three specific proteins that the yeast normally uses as “grip points” to attach to vaginal cells.
–It rebalances two immune signaling molecules that control inflammation. Specifically it lowers IL-2 and raises IL-4 which calms down the inflammatory damage caused by the infection.
By blocking the yeast’s ability to grab onto vaginal cells and by calming the inflammatory response, berberine shows promise as a natural, plant-derived treatment option for this type of yeast infection, potentially offering an alternative or complement to existing antifungal drugs, especially as resistance to those drugs grows.
The above statements have not been evaluated by the FDA and are not intended to diagnose, treat or cure any disease.
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